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These big five drug test kits test for the top five drugs tested for by employers, parole officers, coaches and parents: THC, Opiates, Cocaine, Amphetamines and Meth. The choice of the big five was determined by the NIDA (National Institute on Drug Abuse) in early drug legislation for federal employees and gradually became the norm for drug testing programs throughout the United States. Although private employers and government agencies may choose to test for more than just the big five, you can be almost 100% certain that at least these five will be tested for in any workplace program.